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T5530 Sigma

Monoclonal Anti-τ (Tau) antibody produced in mouse

clone TAU-2, ascites fluid

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Alzheimer′s Disease, Antibodies for Cell Biology, Antibodies for Neural Stem Cells,
species reactivity   human, monkey, chicken, bovine
application(s)   immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
  microarray: suitable
  western blot: 1:1,000 using a fresh total bovine brain extract or an enriched microtubule protein preparation
clone   TAU-2, monoclonal
antibody form   ascites fluid
isotype   IgG1
mol wt   antigen mol wt 55-62 kDa
contains   15 mM sodium azide
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... MAPT(4137)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

bovine microtubule-associated proteins (MAPs)

General description

The antibody reacts exclusively with the chemically heterogeneous τ in both the phosphorylated and non-phosphorylated form. The antibody does not react with other MAPs or with tubulin. In immunohistochemical staining, it localizes τ along microtubules in axons, somata, dendrites and astrocytes, and on ribosomes. The antibody may be used for staining of τ in Alzheimer neurofibrillary tangles in sections of human brain tissue.

The best known microtubule associated proteins (MAPs) which copurify with microtubules are MAP2 and Tau. These two proteins are heat stable and stimulate formation of the microtubule polymer from purified tubulin subunits. Tau is chemically heterogenous, however, limited protolysis has demonstrated that the different eletrophoretic species are closely related. Tau is immunologically distinct from the other MAPs, namely MAP1, MAP2 and MAP5. Localization studies have demonstrated that Tau is intimately associated with the filamentous structures which compose the neurofibrillary tangles as found in an Alzheimer′s disease brain.

Application

Mouse monoclonal clone TAU-2 anti-Tau antibody maybe used to study microtubule associated proteins (MAP) expression and cytological localization in various tissue and cell lines, under different developmental and environmental circumstances.

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