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T5644 Sigma

β-Bungarotoxin from Bungarus multicinctus (Formosan Banded Krait)

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cholinergics, Neuroscience, Neurotransmission,
solubility   H2O: easily soluble
storage temp.   −20°C

Description

Preparation Note

β-Bungarotoxin is easily soluble in water.

Application

β-Bungarotoxin has been used to study the changes in its neurotoxic actions in the presence of suramin6. This toxin has also been used to analyze neuromuscular functions in rats7.

Biochem/physiol Actions

β-Bungarotoxin is reported to block potassium (K+) currents in frog and mouse motor nerves8. Furthermore, this toxin inhibits phorbol-ester-induced phosphorylation of synapsin I, GAP-43 and MARCKS in rat brains9.

Phospholipase A2 neurotoxin; destroys synaptic vesicles and inhibits acetylcholine release.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
EI6201000
Protocols & Articles
Peer-Reviewed Papers
15

References

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