• USA Home
  • T5651 - Tetrodotoxin with Citrate Buffer

EMAIL THIS PAGE TO A FRIEND
T5651 Sigma

Tetrodotoxin with Citrate Buffer

pH 4.8, powder

Synonym: Fugu poison, Maculotoxin, TTX, Tarichatoxin

Purchase

Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Fish, Ion Channels, Monovalent Ion Channels,
InChI Key   CFMYXEVWODSLAX-IXUBDLNJSA-N
form   powder
availability   not available in USA
pH   4.8
solubility   H2O: soluble (stable at pH 4-5 if stored frozen)
  strong acid or alkaline solutions: unstable (destroyed by boiling at pH 2.)
storage temp.   2-8°C
Gene Information   rat ... Scnn1g(24768)

Description

Application

Tetrodotoxin has been used to study its effects on microglial functions in rats2. This toxin has also been used to inactivate lateral magnocellular nucleus of the nidopallium (LMAN) in juvenile zebra finch. This study reported that the toxin causes a decrease in sequence and acoustic variability which result in the production of a stereotyped song by the motor pathway3.

Packaging

Vial contains 1 mg of tetrodotoxin and approx. 5 mg citrate buffer, pH 4.8.

Preparation Note

The product is water soluble and stable at pH 4-5 if it is stored frozen. It is unstable in strong acid and alkaline solutions and is rapidly destroyed by boiling at pH 2 and below.

Biochem/physiol Actions

Reversible, selective blocker of Na+ channels; blocks propagation of impulses in excitable membranes. Used to characterize sodium channels in excitable membranes and to study the role of sodium channels in normal physiology and disease.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3462 6.1 / PGI
WGK Germany 
3
RTECS 
IO1450000

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

Set your institution to view full text papers.
Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?