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T5694 Sigma

TRAIL human

recombinant, expressed in NSO cells, >97% (SDS-PAGE), lyophilized powder

Synonym: Apo2 Ligand, Apo2L, TL2, TNF-related apoptosis-inducing ligand

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Properties

Related Categories Apoptosis and Cell Cycle, Cell Biology, Cell Signaling and Neuroscience, Death Receptor Ligands, Death Receptors, Ligands and Antibodies More...
recombinant   expressed in NSO cells
description   N-terminal 6X histidine-tagged extracellular domain
assay   >97% (SDS-PAGE)
form   lyophilized powder
mol wt   mol wt 24 kDa by SDS-PAGE
  predicted mol wt ~21 kDa
impurities   endotoxin, tested
storage temp.   −20°C
Gene Information   human ... TNFSF10(8743)

Description

Analysis Note

Induces cytotoxicity in mouse L-929 cells in the presence of actinomycin D.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 0.5 mg bovine serum albumin.

Application

TRAIL human was used to induce cytotoxicity in A549, a human lung carcinoma cell line.

Biochem/physiol Actions

TNF-related apoptosis-inducing ligand (TRAIL) is a type II transmembrane protein that belongs to TNF family. It is present in both soluble as well as membrane-bound form and can induce rapid apoptosis of various transformed cell lines but not the normal cells. Additionally, the product can also induces apoptotic cell death in TRAIL-sensitive U343MGcells.

Type II transmembrane protein of the TNF superfamily. Ligand for apoptosis-inducing death receptors DR4 and DR5, decoy receptors DcR1 and DcR2, and osteoprotegerin. Approximately 28% amino acid sequence identity to FAS ligand. Human and mouse TRAIL share 65% sequence identity.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

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Peer-Reviewed Papers
15

References

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