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T5819 Sigma

TRAIL Receptor 2/Fc Chimera from mouse

>95% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder

Synonym: DR5, MK, TRICK2

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Properties

Related Categories Apoptosis and Cell Cycle, Cell Biology, Cell Signaling and Neuroscience, Death Receptors, Ligands and Antibodies, Death and Decoy Receptors More...
recombinant   expressed in baculovirus infected Sf21 cells
assay   >95% (SDS-PAGE)
form   lyophilized powder
mol wt   calculated mol wt ~40 kDa
  mol wt ~49 kDa by SDS-PAGE (reducing)
impurities   endotoxin, tested
storage temp.   −20°C
Gene Information   mouse ... Tnfrsf10b(21933)

Description

Analysis Note

Inhibits apoptosis of mouse L929 cells treated with 20 ng/ml recombinant human TRAIL or 12 ng/ml cross-linked recombinant human TRAIL.

Other Notes

Extracellular domain of mouse TRAIL R2 (a.a. 1-177) fused to the C-terminal Fc region of human IgG1.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Application

TRAIL Receptor 2/Fc Chimera from mouse was used to study apoptosis induced by acetyl-keto-beta-boswellic acid isolated from Boswellia carterri and Boswellia serrata in prostate cancer cells via death receptor 5-mediated pathway.

Biochem/physiol Actions

Member of the TNFR superfamily that binds TRAIL and induces apoptosis in a variety of cell types. The degree of homology between the death domains of mouse TRAIL R2 and either human TRAIL R1 or TRAIL R2 is 76% and 79%, respectively.

TRAIL Receptor 2 also refers as DR5 or TRICK2 belongs to TNF receptor family and can induce apoptosis via FADD and caspase-8. It also promotes NF-κ-B activation.

Price and Availability


Flow Cytometry Instruments
Safety & Documentation

Safety Information

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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