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T6031 Sigma

DL-Thiorphan

≥98% (TLC)

Synonym: (±)-N-(3-Mercapto-2-benzylpropionyl)glycine, DL-3-Mercapto-2-benzylpropanoylglycine

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   LJJKNPQAGWVLDQ-UHFFFAOYSA-N
assay   ≥98% (TLC)
solubility   ethanol: soluble49.00 - 51.00  mg/mL, clear, colorless
Gene Information   human ... ACE(1636), ECE1(1889)
rat ... Ace(24310), Mme(24590)

Description

Biochem/physiol Actions

Enkephalinase inhibitor.

Packaging

5, 25 mg in glass bottle

Preparation Note

DL-Thiorphan is soluble in ethanol at 49.00 - 51.00 mg/ml and yields a clear, colorless solution.

Application

DL-Thiorphan has been used to evaluate the activity of NEP-dependent neutral endopeptidase4. DL-Thiorphan has also been used for determining NEP enzymatic activity using fluorimetric assays5.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability


Biomedical Applications
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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