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T6137 Sigma

Trioxsalen

≥98% (HPLC), powder

Synonym: 2,5,9-Trimethylfuro[3,2-g]benzopyran-7-one, 4,5′,8-Trimethylpsoralen, TMP, Trisoralen

Properties

Related Categories Apoptosis and Cell Cycle, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology,
assay   ≥98% (HPLC)
form   powder
color   white
mp   229-231 °C(lit.)
solubility   chloroform: soluble50  mg/mL, clear, colorless to faintly yellow
fluorescence   λex 269 nm; λem 445 nm in methanol
  λex 321 nm; λem 445 nm (bound to DNA in Tris, pH 8.1)
storage temp.   −20°C

Description

Packaging

1 g in glass bottle

100, 500 mg in glass bottle

Preparation Note

Trioxsalen is soluble in chloroform at 50 mg/ml and yields a clear, colorless to faint yellow solution.

Application

Trioxsalen has been used for mutagenesis of N2 worms4,5.

Biochem/physiol Actions

Photochemical crosslinker of DNA that has been used as a probe for nucleic acid structure and function. Trioxsalen has also been used to crosslink DNA onto mica surfaces.

Price and Availability

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