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T6193 Sigma

Tyrphostin AG 1112

≥98%, solid

  • CAS Number 153150-84-6

  • Empirical Formula (Hill Notation) C15H10N6

  • Molecular Weight 274.28

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Description

Biochem/physiol Actions

Casein kinase II inhibitor.

Tyrphostin AG 1112 is a Bcr-Abl kinase blocker that can activate the terminal differentiation of K562 cells and the purging of Ph+ cells. AG 1112 can also interact with anti-Fas receptor antibody to stimulate apoptosis1.

Preparation Note

Tyrphostin AG 1112 is soluble in DMSO and is insoluble in ethanol.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Abl page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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DISCOVER Bioactive Small Molecules

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

Articles

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Phosphorylation is a ubiquitous cellular regulatory mechanism that mediates signal transduction pathways, which carry signals from the cell surface to the nucleus or cytoplasm, by altering the activi...
Keywords: Apoptosis, Bioactive small molecules, Cancer, Diseases, Inflammation, Metabolism, Neurodegenerative Diseases, Phosphorylations, Transduction

Peer-Reviewed Papers
15

References

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