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  • T6277 - Monoclonal Anti-Troponin T antibody produced in mouse

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T6277 Sigma

Monoclonal Anti-Troponin T antibody produced in mouse

clone JLT-12, ascites fluid

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Cardiac Stem Cells, Antibodies for Cell Biology, Antibodies for Stem Cell Biology,
species reactivity   bovine, rabbit, rat, chicken
application(s)   immunohistochemistry: suitable
  western blot: 1:200 using rabbit total skeletal muscle extract
clone   JLT-12, monoclonal
antibody form   ascites fluid
isotype   IgG1
contains   15 mM sodium azide
shipped in   dry ice
storage temp.   −20°C
Gene Information   rat ... Tnnt1(171409), Tnnt2(24837), Tnnt3(24838)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

Troponin T from rabbit skeletal muscle.

General description

Troponin T is a vital subunit of troponin. Troponin T is a comma or rod shaped protein with a length of 185-205 Å. Troponin T is positioned in the actin helix groove and is extended along the filament of troponin. Life span of serum troponin T is 120 minutes. N- terminal end of the protein is enriched in negatively charged residues and C- terminal end is enriched with positively charged residues. This uneven distribution of charges in troponin T facilitates its aggregation at physiological salt concentration. In humans, cardiac troponin T exists in four isoforms, out of which three are expressed in the fetus and one isoform is expressed in the adult heart.

Application

Monoclonal Anti-Troponin T antibody produced in mouse has been used in following studies:
• Western blot analysis.
• Immunocytochemical analysis.
• Immunofluorescence.

Biochem/physiol Actions

Troponin T is a subunit of troponin, which facilitates binding of troponin to tropomyosin. It also plays a crucial role in muscle contraction. Cardiac troponin T acts as a potential marker for the detection of acute myocardial infarction (MI). Apart from facilitating binding of troponin components to the actin-tropomyosin filament, it is has an essential role in the regulation of actomyosin ATPase activity. Cardiac troponin T gene mutation leads to hypertrophic cardiomyopathy.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  2
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Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Inflammation, Molecular biology, Phosphorylations, Purification, Western blot

Peer-Reviewed Papers
15

References

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