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T6638 Sigma

Tolnaftate

Synonym: Methyl-(3-methylphenyl)carbamothioic acid O-2-naphthyl ester

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics T-Z, Antifungal, Biochemicals and Reagents,
InChI Key   FUSNMLFNXJSCDI-UHFFFAOYSA-N
form   powder
color   white
solubility   chloroform: soluble50 mg/mL
Mode of action   enzyme | inhibits
antibiotic activity spectrum   fungi
storage temp.   2-8°C

Description

Packaging

1G,5G

Application

Tolnaftate is used to study the mechanism of ergosterol (sterol) biosynthesis at the rate-limiting step of squalene epoxidase inhibition. Tolnaftate is clinically used to treat cutaneous infections such as athlete′s foot, jock itch, and ringworm. It also has been used as a comparator compound for antifungal efficiency studies.

Biochem/physiol Actions

Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms. Tolnaftate inhibits biosynthesis of aflatoxin.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. T6638.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
Protocols & Articles
Peer-Reviewed Papers
15

References

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