• USA Home
  • T7039 - Transforming Growth Factor-β1 human

EMAIL THIS PAGE TO A FRIEND
T7039 Sigma

Transforming Growth Factor-β1 human

TGF-β1, recombinant, expressed in CHO cells, powder, suitable for cell culture

Synonym: TGF-β1, hTGF-β1

Purchase

Description

Analysis Note

The biological activity of TGF-β1 is measured in culture by inhibition of mouse IL-4-dependent proliferation of mouse HT-2 cells.

Biochem/physiol Actions

Transforming growth factor-β1 (TGF-β1) is produced by many cell types, but is reported to be most concentrated in mammalian platelets, where it is present at approximately four times the level of TGF-β2.

TGF-β1 is a 25 kDa multifunctional peptide capable of influencing cell proliferation, differentiation, and other functions in a wide range of cell types. Transformed as well as non-neoplastic tissues release transforming growth factors and essentially all cells possess a specific TGF-β1 receptor. The multi-modal nature of TGF-β1 is seen in its ability to stimulate or inhibit cellular proliferation. In general, cells of mesenchymal origin appear to be stimulated by TGF-β1; whereas, hepatocytes, T and B lymphocytes, keratinocytes, and many epithelial cells are inhibited by the peptide. TGF-β1 interacts with Epidermal Growth Factor, Platelet Derived Growth Factor, Fibroblast Growth Factor, and T Cell Growth Factor either by enhancing or antagonizing their characteristic actions. TGF-β1 plays a fundamental role in tissue growth and differentiation by involvement in adipogenesis, myogenesis, chondrogenesis, osteogenesis, epithelial cell differentiation, and immune cell function.

Physical form

Lyophilized from a 0.2 μm filtered aqueous solution.

Price and Availability


Filter out uncertainty.

All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles

Articles

Cellular Derived Blood Proteins and Enzymes

Cell damage is induced by reactive oxygen species (ROS). ROS are either free radicals, reactive anions containing oxygen atoms, or molecules containing oxygen atoms that can either produce free radic...
BioFiles 2006, 1.5, 4.
Keywords: Aerobic, Alzheimer Disease, Bacterial conjugations, Biofiles, Cancer, Metabolism, Oxidations, Parkinson Disease, Reductions, Respiration

Transforming Growth Factor (TGF) Superfamily

The transforming growth factor-β (TGF-β) superfamily of cytokines include the structurally related subfamily of TGF-βs, the subfamily of bone morphogenic proteins (BMP), decapentaplegic (dpp) and Vg1...
Jennifer Fries
BioFiles 2009, 4.5, 21.
Keywords: Cancer, Gene expression, Growth factors, Ligands, Phosphorylations, Transduction, Type

Peer-Reviewed Papers
15

References

Set your institution to view full text papers.
Related Products

comparable product

Product #

Description

Add to Cart

H8541 Transforming Growth Factor-β1 human, TGF-β1, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture

recommended

Product #

Description

Add to Cart

H8666 Transforming Growth Factor-β2 human, TGF-β2, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture

related product

Product #

Description

Add to Cart

T2815 Transforming Growth Factor-β2 human, TGF-β2, recombinant, expressed in NSO cells, powder, suitable for cell culture
92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?