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T7076 Sigma

Monoclonal Anti-Thimet Oligopeptidase 1 antibody produced in mouse

1 mg/mL, clone IVD6, purified immunoglobulin, buffered aqueous solution

Synonym: Anti-THOP1

Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Neurobiology, Antibodies to Neural Enzymes, Neuroscience,
species reactivity   human, monkey
application(s)   microarray: suitable
  western blot: 0.5-1.0 μg/mL using SY5Y cell extract.
clone   IVD6, monoclonal
concentration   1 mg/mL
antibody form   purified immunoglobulin
form   buffered aqueous solution
isotype   IgG2b
mol wt   antigen mol wt ~85 kDa
shipped in   dry ice
storage temp.   −20°C
Gene Information   human ... THOP1(7064)
biological source   mouse
conjugate   unconjugated

Description

Immunogen

synthetic peptide corresponding to amino acids 47-63 of human THOP1.

Antigen Background

THOP1 is a metalloprotease that is able to cleave a synthetic peptide encompassing the amino-terminus of amyloid b-peptideand generate amyloidogenic fragments from recombinant human Amyloid Precursor Protein.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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