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T7154 Sigma

Tyr-Ile-Gly-Ser-Arg

≥97% (HPLC)

Synonym: Laminin Fragment 929-933

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Description

Amino Acid Sequence

Tyr-Ile-Gly-Ser-Arg

Biochem/physiol Actions

Tyr-Ile-Gly-Ser-Arg is a fragment of domain III of the laminin B1 chain . It is a major receptor binding site in laminin. It competes with laminin for the cell surface receptor. It is an inhibitor of tumor growth and metastasis.

Tyr-Ile-Gly-Ser-Arg (YIGSR) is a pentapeptide of the protein laminin that reduces the lung colony formation in mice administered with melanoma cells as well as can block the invasiveness of the cells in vitro. It inhibits the increased expression of endothelial nitric-oxide synthase in primary porcine aortic endothelial cells.

Preparation Note

Tyr-Ile-Gly-Ser-Arg dissolves in water at 1 mg/ml to yield a clear, colorless solution.

Application

Tyr-Ile-Gly-Ser-Arg (YIGSR) can be used at the interface between the conjugated polymer and the tissue for the engineering of tissue interface. The product can also be used to study the role of integrins β1, α6, and α3 in promoting type II epithelial differentiation during lung maturation in the fetus.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles

Articles

Conjugated Polymers for the Engineering of Device/Tissue Interface

There is considerable interest in the development of conjugated, electronically and ionically active polymers for interfacing active biomedical devices with living tissue.1-6 Conjugated polymers offe...
David C. Martin*, Laura K. Povlich and Kathleen E. Feldman
Material Matters 2010, 5.3, 68.
Keywords: Adhesion, Applications, Company, Cycloadditions, Deposition, Magnetic resonance spectroscopy, Materials Science, Methods, Polymerization reactions, Reductions, Sequences, Solution polymerization

Peer-Reviewed Papers
15

References

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