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T7189 Sigma

Tumor Necrosis Factor Soluble Receptor II (TNF sRII)/Fc Chimera human

>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, cell culture tested

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Properties

Related Categories Cancer Research, Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Cytokines & Growth Factors,
recombinant   expressed in NSO cells
assay   >95% (SDS-PAGE)
form   lyophilized powder
impurities   endotoxin, tested
suitability   cell culture tested
storage temp.   −20°C
Gene Information   human ... TNFRSF1B(7133)

Description

Analysis Note

The biological activity is measured by its ability to neutralize the TNF-α mediated cytotoxicity in mouse L-929 cells in the presence of the metabolic inhibitor actinomycin D.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline

Application

Tumor Necrosis Factor Soluble Receptor II (TNF sRII)/Fc Chimera human can be used as a test compound for analyzing the interaction between tumor necrosis factor (TNF) and its two soluble receptors by using surface plasmon resonance (SPR) technique.

Biochem/physiol Actions

Tumor Necrosis Factor Soluble Receptor II (TNF sRII)/Fc Chimera human belongs to TNF family of receptors and mediates the metabolic effects of TNF-α. Tumor Necrosis Factor Soluble Receptor II blocks the TNF-α-induced apoptosis and hence regulates the TNF-α function. It also has a pivotal role in neutralizing the biological activities of both TNF-α and TNF-β.

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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