Nα-Tosyl-L -lysine chloromethyl ketone hydrochloride
≥96% (TLC), powder
DOWNLOAD MSDS (PDF)Synonym:
(3S)
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CAS Number 4272-74-6
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Empirical Formula (Hill Notation) C14H21ClN2O3S · HCl
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Molecular Weight 369.31
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Beilstein Registry Number 7106867
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EC Number 224-266-4
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MDL number MFCD00065395
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PubChem Substance ID 24278752
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Popular Documents: Product Information Sheet (PDF) | FTNMR (PDF)
Properties
| Related Categories | A to C, Adenylate cyclase, Bioactive Small Molecules, Biochemicals and Reagents, Broad Spectrum Inhibitors of Proteolytic Enzyme Classes, |
| assay | ≥96% (TLC) |
| form | powder |
| potency | 10-100 μM effective concentration |
| solubility | H2O: soluble50 mg/mL |
| storage temp. | −20°C |
| Gene Information | human ... NFKB1(4790), NFKB2(4791) |
Description
Biochem/physiol Actions
Blocks the LPS- or cytokine-induced activation of nuclear factor κB (NF-κB), which, in turn, blocks the induction of iNOS and COX-2 transcription. Blocks activation of pp70s6k by all mitogens. Blocks apoptosis in cell lines by inhibiting the processing of caspases in some cell lines and to some stimuli.
Caution
Stable at least two years when stored desiccated at −20°C.
Price and Availability
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(TLCK treated to inactivate residual tryspin activity), Type VII, essentially salt-free, lyophilized powder, ≥40 units/mg protein
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