|Related Categories||A to C, Adenylate cyclase, Bioactive Small Molecules, Biochemicals and Reagents, Broad Spectrum Inhibitors of Proteolytic Enzyme Classes,|
|potency||10-100 μM effective concentration|
|solubility||H2O: soluble50 mg/mL|
|Gene Information||human ... NFKB1(4790), NFKB2(4791)|
Blocks the LPS- or cytokine-induced activation of nuclear factor κB (NF-κB), which, in turn, blocks the induction of iNOS and COX-2 transcription. Blocks activation of pp70s6k by all mitogens. Blocks apoptosis in cell lines by inhibiting the processing of caspases in some cell lines and to some stimuli.
Stable at least two years when stored desiccated at −20°C.
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(TLCK treated to inactivate residual tryspin activity), Type VII, essentially salt-free, lyophilized powder, ≥40 units/mg protein
microbial, ≥90% (HPLC)
≥97% (TLC), powder
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P261-P305 + P351 + P338|
|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Gloves|
|Hazard Codes (Europe)||Xi|
|Risk Statements (Europe)||36/37/38|
|Safety Statements (Europe)||26-36|
Evidence for involvement of the proteasome complex (26S) and NFκB in IL-1β-induced nitric oxide and prostaglandin production by rat islets and RINm5F cells. Kwon, G., et al. Diabetes 47, 583-591, (1998)
The serine protease inhibitors tosylphenylalanine chloromethyl ketone and tosyllysine chloromethyl ketone potently inhibit pp70s6k activation. Grammer, T.C., , and Blenis, J. J. Biol. Chem. 271, 23650, (1996)
Inhibitors of trypsin-like serine proteases inhibit processing of the caspase Nedd-2 and protect PC12 cells and sympathetic neurons from death. Stefanis, L., et al. J. Neurochem. 69, 1425-1437, (1997)
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