Paclitaxel
from Taxus brevifolia, ≥95% (HPLC), powder
DOWNLOAD MSDS (PDF)-
CAS Number 33069-62-4
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Empirical Formula (Hill Notation) C47H51NO14
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Molecular Weight 853.91
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Beilstein Registry Number 1420457
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MDL number MFCD00869953
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PubChem Substance ID 24277878
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Popular Documents: Product Information Sheet (PDF) | Specification Sheet (PDF)
Properties
| Related Categories | Antibiotics, Antibiotics A to Z, Antibiotics N-S, Antibiotics by Application, Antineoplastic and Immunosuppressive Antibiotics, |
| biological source | from Taxus brevifolia |
| assay | ≥95% (HPLC) |
| form | powder |
| color | white |
| mp | 213 °C (dec.)(lit.) |
| solubility | DMSO: soluble50 mg/mL (can be stored frozen for several months) |
| H2O: soluble (hydrolyzes) |
Description
Caution
Paclitaxel undergoes transesterification in methanol and hydrolyzes in aqueous solutions.
Packaging
1, 5, 25 mg in glass bottle
Biochem/physiol Actions
Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase. The microtubule damage induces apoptosis through a JNK-dependent pathway followed by a JNK-independent pathway, perhaps related to the activation of protein kinase A (PKA) or of Raf-1 kinase, resulting in phosphorylation of Bcl-2. A major metabolite via CYP2CB is 6α-hydroxypaclitaxel (6α-OHP).
Price and Availability
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