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T7444 Sigma

Anti-phospho-Tau (pSer404) antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

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Properties

Related Categories Alphabetical Index, Antibodies, Antibodies for Alzheimer′s Disease, Antibodies for Cell Biology, Antibodies for Kinase/Phosphatase Biology,
species reactivity   human, rat, mouse
application(s)   immunohistochemistry: suitable
  western blot: 1:1,000
clone   polyclonal
antibody form   affinity isolated antibody
form   buffered aqueous glycerol solution
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... MAPT(4137)
mouse ... Mapt(17762)
rat ... Mapt(29477)
biological source   rabbit
conjugate   unconjugated

Description

Immunogen

chemically synthesized phosphopeptide derived from the region of human tau that contains serine404.

General description

Tau is a microtubule-associated phosphoprotein that is present in the axons of nerve cells. It stabilizes microtubules and mediates the polymerization of tubulin. Phosphorylation of Tau regulates its cellular functions. Hyperphosphorylation of Tau has been linked to neurodegenerative disorders such as Alzheimer’s disease . Anti-phospho-Tau (pSer404) antibody specifically reacts with Tau (pSer404) (45-68 kDa) in humans, mice and rats.

Physical form

Solution in Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, with 50% glycerol, 1.0 mg/ml BSA (IgG and protease free) and 0.05% sodium azide.

Application

Anti-phospho-Tau (pSer404) antibody may be used in western blot (1:1000), immunoblot (1:1000) and immunohistochemistry.

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Safety Information

RIDADR  NONH for all modes of transport
WGK Germany  3
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Keywords: Amplification, Buffers, Cell biology, Enzyme-linked immunosorbent assay, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Molecular biology, Phosphorylations, Purification, Western blot

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