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T7508 Sigma

Tetracaine hydrochloride


Synonym: 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester, Amethocaine hydrochloride


Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Ion Channels,
assay   ≥99%
solubility   alcohol: solublesoluble 40 parts of solvent
  chloroform: solublesoluble in 30 parts of solvent
  acetone: insoluble
  benzene: insoluble
  diethyl ether: insoluble



Topical ophthalmic anesthetic; used for spinal anesthesia

Tetracaine hydrochloride has been used for studying the pharmacological effects of spinal anesthesia1. Tetracaine hydrochloride has also been used as a component of protease digestion buffers2.

Biochem/physiol Actions

Blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum.

Preparation Note

Tetracaine hydrochloride dissolves in water at 50 mg/ml to yield a clear, colorless solution. It is also soluble in 40 parts alcohol and 30 parts chloroform. However, it is practically insoluble in ether benzene or acetone.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®,1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Cyclic Nucleotide-Gated (CNG) and Hyperpolarization Activated Cyclic Nucleotide-Gated (HCN) Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Price and Availability

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≥98% (TLC)


meets USP testing specifications

Tetracaine hydrochloride

meets USP testing specifications

Tetracaine hydrochloride

Sigma Reference Standard

Tetracaine hydrochloride

pharmaceutical secondary standard; traceable to USP and PhEur

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