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T7883 Sigma

Trimethoprim

≥98% (HPLC)

Synonym: 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine, NSC 106568

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Properties

Related Categories Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics T-Z, Biochemicals and Reagents,
InChI Key   IEDVJHCEMCRBQM-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   white powder
solubility   chloroform/ethanol (1:1): soluble50 mg/mL
  DMSO: soluble
Mode of action   DNA synthesis | interferes
  enzyme | inhibits
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
  mycobacteria
storage temp.   2-8°C
Gene Information   human ... DHFRP1(573971), KCNH1(3756)
rat ... Dhfr(24312)

Description

Frequently Asked Questions

Frequently Asked Questions are available for this Product.

Application

Primarily used as an antibacterial agent. Dihydrofolate reductase inhibitor with selectivity for the prokaryote enzyme.

Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections.

Biochem/physiol Actions

The combination of trimethoprim and sulfamethoxazole interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis.

Protocols & Applications

Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

Price and Availability

Suggested Laboratory Gloves


Laboratory GlovesThis substance has been tested against several types of hand protection for CE compliance. Click below to find the recommended gloves for handling this product.



Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
UV8225000
Protocols & Articles
Peer-Reviewed Papers
15

References

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