Synonym: Fugu poison, Maculotoxin, TTX, Tarichatoxin
|Related Categories||Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Fish, Ion Channels,|
|solubility||dilute citrate or acetate buffer: soluble1 mg/mL (dissolve at pH 4-5. Aqueous solutions, pH 4-5, are stable if stored frozen.)|
|strong acid or alkaline solutions: unstable (destroyed by boiling at pH 2.)|
|Gene Information||rat ... Scnn1g(24768)|
Tetrodotoxin is soluble in dilute citrate or acetate buffer at 1 mg/ml (pH 4-5). Aqueous solutions are stable at pH 4-5 if stored frozen. However, tetrodotoxin is unstable in strong acid or alkaline solutions and is destroyed by boiling at pH2.
Tetrodotoxin has been used as standard during HPLC-based analysis of biotoxins from P. punctata tentacles whole crude extract (PHY-N)1. Tetrodotoxin has also been used to study its effects on low-threshold transient (LTT) Ca2+ currents in rat hippocampal interneurons2.
Reversible, selective blocker of Na+ channels; blocks propagation of impulses in excitable membranes. Used to characterize sodium channels in excitable membranes and to study the role of sodium channels in normal physiology and disease.
Certificate of Analysis
Certificate of Origin
|Hazard statements||H300 +H310 + H330|
|Precautionary statements||P260-P264-P280-P284-P301 + P310-P302 + P350|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges|
|Hazard Codes (Europe)||T+|
|Risk Statements (Europe)||26/27/28|
|Safety Statements (Europe)||22-36/37/39-45|
|RIDADR||UN 3462 6.1 / PGI|
2. Low-threshold transient calcium current in rat hippocampal lacunosum-moleculare interneurons: kinetics and modulation by neurotransmitters. Fraser DD and MacVicar BA J. Neurosci. 11(9), 2812-20, (1991)
Mutation of the protein kinase C site in borna disease virus phosphoprotein abrogates viral interference with neuronal signaling and restores normal synaptic activity. Prat CM PLoS Pathog. 5(5), e1000425, (2009)
Simultaneous monitoring of presynaptic transmitter release and postsynaptic receptor trafficking reveals an enhancement of presynaptic activity in metabotropic glutamate receptor-mediated long-term depression. Xu W, Tse YC, Dobie FA, et al. J. Neurosci. 33(13), 5867-77, (2013)
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