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T8024 Sigma

Tetrodotoxin

≥98% (HPLC), powder

Synonym: Fugu poison, Maculotoxin, TTX, Tarichatoxin

Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Fish,
assay   ≥98% (HPLC)
form   powder
color   white
solubility   dilute citrate or acetate buffer: soluble1 mg/mL (dissolve at pH 4-5. Aqueous solutions, pH 4-5, are stable if stored frozen.)
  strong acid or alkaline solutions: unstable (destroyed by boiling at pH 2.)
storage temp.   2-8°C
Gene Information   rat ... Scnn1g(24768)

Description

Preparation Note

Tetrodotoxin is soluble in dilute citrate or acetate buffer at 1 mg/ml (pH 4-5). Aqueous solutions are stable at pH 4-5 if stored frozen. However, tetrodotoxin is unstable in strong acid or alkaline solutions and is destroyed by boiling at pH2.

Application

Tetrodotoxin has been used as standard during HPLC-based analysis of biotoxins from P. punctata tentacles whole crude extract (PHY-N)1. Tetrodotoxin has also been used to study its effects on low-threshold transient (LTT) Ca2+ currents in rat hippocampal interneurons2.

Biochem/physiol Actions

Reversible, selective blocker of Na+ channels; blocks propagation of impulses in excitable membranes. Used to characterize sodium channels in excitable membranes and to study the role of sodium channels in normal physiology and disease.

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