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T8316 Sigma

Tertiapin

>95%

  • Empirical Formula (Hill Notation) C106H176N34O23S5

  • Molecular Weight 2455.07

  •  MDL number MFCD02094633

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Description

Amino Acid Sequence

Ala-Leu-Cys-Asn-Cys-Asn-Arg-Ile-Ile-Ile-Pro-His-Met-Cys-Trp-Lys-Lys-Cys-Gly-Lys-Lys-NH2

Preparation Note

Tertiapin dissolves in water at 1 mg/ml to yield a clear solution.

Application

Tertiapin was used for developing a novel CZE-DAD method for analyzing the honeybee venom.

Biochem/physiol Actions

A potent inhibitor of the inward-rectifier K+ channels, blocked a G-protein-gated channel (GIRK1/4) and the ROMK1 channel with nanomolar affinities, however a closely related channel, IRK1, was insensitive to tertiapin. Thus, tertiapin is a tool for purifying functional channels as well as for screening pharmaceutical agents against these channels.

Tertiapin is a peptide isolated from honey bee venom, which is a selective IKACh blocker that prolongs the atrial effective refractory period and terminates the atrial fibrillation. It is a selective and potent inhibitor of muscarinic K+ channels in rabbit cardiac myocytes.

Price and Availability


Detect Your Unseen Protein

All labs need water

Amicon Ultra Centrifugal Filters
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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