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T8690 Sigma

Thioredoxin human

≥90% (SDS-PAGE), recombinant, expressed in E. coli (N-terminal histidine tagged), essentially salt-free, lyophilized powder, ≥5 U/mg

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cell Stress, Nitric Oxide and Cell Stress, Oxidative Stress Proteins and Reagents More...
recombinant   expressed in E. coli (N-terminal histidine tagged)
assay   ≥90% (SDS-PAGE)
form   essentially salt-free, lyophilized powder
storage temp.   −20°C
Gene Information   human ... TXN(7295)

Description

Biochem/physiol Actions

Human Thioredoxin is a recombinant, N-terminal histidine tagged protein. The product induces proliferation in lymphoid cells, fibroblasts as well as in numerous human solid tumor cell lines.The product also stimulates growth in normal as well as leukemic B cell, modifies the transcriptional activity of AP-1and inhibits the apoptosis signal-regulating kinase 1 (ASK1).

Mediates the reduction of disulfide bonds in proteins.

General description

Cloned from Jurkat cell cDNA. Identical to the ADF/Trx (GenBank® Accession Number X77584) and the thioredoxin from human placenta (GenBank® Accession Number AF085844).

Unit Definition

One unit will cause a ΔA650 of 1.0 in 1 min at 25 °C in the insulin reduction assay.

Application

Thioredoxin human can be used for in vitro thioredoxin assay. The product can also be used for assessing Thioredoxin reductase (TRXR) enzyme activity.

Legal Information

GenBank is a registered trademark of United States Department of Health and Human Services

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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06693 Timestrip Plus -20 °C

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