|Related Categories||Antitumor Agents, Bioactive Small Molecules, Cancer Research, Cell Biology, Cell Signaling and Neuroscience,|
|solubility||DMSO: >10 mg/mL|
T0070907 is soluble in DMSO at a concentration that is greater than 10 mg/ml.
T0070907 or Benzamide has been used as a ADP-ribosyltransferase (ADPRT) inhibitor in rat hippocampal slices1. It has also been used for urine analysis in patients diagnosed with acute uncomplicated urinary tract infection2.
T0070907 is very similar in structure and activity to the PPAR-γ antagonist GW9662. T0070907 is more potent and has higher selectivity for PPAR-γ over all other subtypes (about 800-fold) whereas GW9662 has been reported to have some PPAR-α agonist activity.
1. An ADP-ribosyltransferase as a potential target for nitric oxide action in hippocampal long-term potentiation. Schuman EM, Meffert MK, Schulman H, et al. Proc. Natl. Acad. Sci. U. S. A. 91(25), 11958-62, (1994)
Peroxisome proliferator-activated receptor gamma inhibition prevents adhesion to the extracellular matrix and induces anoikis in hepatocellular carcinoma cells. Schaefer K.L., et al. Cancer 65, 2251-9, (2005)
T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities. Lee, G., et al. J. Biol. Chem. 277, 19649-57, (2002)
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