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T8785 Sigma

Thyrotropic hormone from porcine pituitary

5 IU/mg

Synonym: TSH, Thyroid stimulating hormone

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, Pituitary Hormones,
packaging   vial of 10 IU
storage temp.   2-8°C
Gene Information   human ... TSHR(7253)
pig ... TSH-BETA(397658)

Description

Biochem/physiol Actions

Thyrotropic hormone also referred to as Thyrotropin or Thyroid stimulating hormone (TSH) belongs to glycoprotein hormone family. The product can enhance vascular endothelial growth factor (VEGF) secretion and angiogenesis in thyroid cancer cell lines. It modifies EGF receptor function in porcine thyroid follicle cells through a cAMP-dependent process and increases the generation of inositol 1,4,5-trisphosphate in human thyroid cells.

Two-chain glycoprotein hormone. The α-chain is not active, biological specificity attributed rather to the β-chain. Activates adenylate cyclase in the thyroid gland, stimulating iodine uptake, thyroxine synthesis and release. Goitrogenic.

Application

Thyrotropic hormone from porcine pituitary can be used as a NCTC-135 medium supplement for isolating the thyroid cells which in turn is used for studying the impact of retinoids on non-transformed cells like thyrocytes. The product can also be used in cell proliferation experiment for studying the impact of increased IGF binding proteins 1 level on the function and growth of the thyroid gland in transgenic mice.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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