Terbinafine hydrochloride
≥98%
DOWNLOAD MSDS (PDF)Synonym:
trans-
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CAS Number 78628-80-5
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Empirical Formula (Hill Notation) C21H25N · HCl
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Molecular Weight 327.89
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MDL number MFCD00145430
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Popular Documents: Specification Sheet (PDF)
Properties
| Related Categories | Antibiotics, Antibiotics A to Z, Antibiotics T-Z, Antifungal, Antimycobacterial, |
| assay | ≥98% |
Description
Biochem/physiol Actions
Mode of Action: Inhibits squalene epoxidase, preventing biosynthesis of ergosterol.
Antimicrobial spectrum: Antifungal and antimycotic. Fungicidal against dermatopytes and some yeasts; fungistatic against Candida albicans.
Terbinafine inhibits squalene monooxygenase thereby blocking the biosynthesis of ergosterol, which is an essential component of fungal cell membranes. The inhibition of squalene monooxygenase also results in the accumulation of squalene. Terbinafine hydrochloride is highly lipophilic and tends to accumulate in skin, nails, and fatty tissues1. It is antifungal and antimycotic. It is fungicidal against dermatopytes and some yeasts and is fungistatic against Candida albicans.
General description
Allylamine derivative.
Application
Terbinafine hydrochloride is a synthetic allylamine antifungal. It is used to treat dermatophyte infections of the toenail/fingernail, ringworm and jock itch1. It is used in adsorption, partition and stability studies2,3.
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