|Related Categories||Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics T-Z, Antibiotics by Application,|
|solubility||acetic acid: soluble25 mg/mL, clear to hazy, yellow to brownish-yellow|
Thiostrepton has been used as a selectable marker for recombinant Streptomyces cultures1,2,3.
1 g in poly bottle
Thiostrepton dissolves in acetic acid at 25 mg/ml to yield a clear to hazy, yellow-yellow brown solution.
Peptide antibiotic that prevents the binding of elongation factor G (EF-G) and GTP to the 50S ribosomal subunit.
Certificate of Analysis
Certificate of Origin
Increasing antibiotic resistance and the lack of new drug development have hindered the success of antibiotics in recent years. Staph aureus is susceptible to a number of antibiotics with various mec...
1. Characterization of the pathway-specific positive transcriptional regulator for actinorhodin biosynthesis in Streptomyces coelicolor A3(2) as a DNA-binding protein. Arias P, Fernández-Moreno MA, and Malpartida F J. Bacteriol. 181(22), 6958-68, (1999)
3. An additional regulatory gene for actinorhodin production in Streptomyces lividans involves a LysR-type transcriptional regulator. Martínez-Costa OH, Martín-Triana AJ, Martínez E, et al. J. Bacteriol. 181(14), 4353-64, (1999)
Influence of thiostrepton binding on the ribosomal GTPase associated region characterized by molecular dynamics simulation. Wolf A, Baumann S, Arndt HD, et al. Bioorg. Med. Chem. 20(24), 7194-205, (2012)
Thiostrepton inhibits stable 70S ribosome binding and ribosome-dependent GTPase activation of elongation factor G and elongation factor 4. Walter JD, Hunter M, Cobb M, et al. Nucleic Acids Res. 40(1), 360-70, (2012)
Combination treatment with bortezomib and thiostrepton is effective against tumor formation in mouse models of DEN/PB-induced liver carcinogenesis. Wang M, Halasi M, Kabirov K, et al. Cell Cycle 11(18), 3370-2, (2012)
Thiostrepton is an inducer of oxidative and proteotoxic stress that impairs viability of human melanoma cells but not primary melanocytes. Qiao S, Lamore SD, Cabello CM, et al. Biochem. Pharmacol. 83(9), 1229-40, (2012)
Micelle-encapsulated thiostrepton as an effective nanomedicine for inhibiting tumor growth and for suppressing FOXM1 in human xenografts. Wang M and Gartel AL Mol. Cancer Ther. 10(12), 2287-97, (2011)
Development of a vector and host system and characterization of replication of plasmid pSQ10 in moderately halophilic Nocardiopsis. Zeng A, Wang T, Xia H, et al. Acta Biochim. Biophys. Sin. (Shanghai) 43(9), 738-43, (2011)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Need larger quantities for your development, manufacturing or research applications?