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T8904 Sigma

Thiabendazole

≥99%, powder

Synonym: 2-(4-Thiazolyl)benzimidazole

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Properties

Related Categories Antibiotics, Antibiotics A to Z, Antibiotics T-Z, Antifungal, Antiparasitic / Antiprotozoal / Anthelminthic,
InChI Key   WJCNZQLZVWNLKY-UHFFFAOYSA-N
assay   ≥99%
form   powder
color   white to off-white
solubility   DMF: soluble50 mg/mL
Mode of action   enzyme | inhibits
antibiotic activity spectrum   fungi
  parasites
Gene Information   human ... CYP2C9(1559)

Description

Packaging

100, 500 g in glass bottle

Application

Thiabendazole (TBZ) is a broad-spectrum antihelminthic and is used to treat parasitic infections in humans. It is used as an agricultural fungicide and as a food preservative. Thiabendazole has been used as a heavy metal chelating detoxification agent. It is used clinically to treat threadworm, cutaneous larva migrans, visceral larva migrans, and trichinosis.

Biochem/physiol Actions

Thiabendazole inhibits anaerobic respiration at the level of mitochondrial helminth-specific enzyme. It acts as a quinol-fumarate reductase (QFR) inhibitor in ,C. jejuni and H. pylori, blocking quinol oxidation to quinone. Thiabendazole suppresses egg and larval production and may inhibit the subsequent development of eggs and larvae which are passed in feces. A proposed route of biotransformation of thiabendazole is the CYP1A2-catalyzed hydroxylation to 5-hydroxythiabendazole, which is metabolized to glucuronide and sulfate conjugates.

Protocols & Applications

Antibiotic Selector for application, solubility, solution stability, working concentration, and mode of action information

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Safety & Documentation

Safety Information

Symbol 
GHS09  GHS09
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
2
RTECS 
DE0700000
Protocols & Articles

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Peer-Reviewed Papers
15

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