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T8931 Sigma

Thyrotropic hormone from bovine pituitary

2 IU/mg protein

Synonym: TSH, Thyroid stimulating hormone, Thyrotropin from bovine pituitary glands

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, Pituitary Hormones,
packaging   vial of 10 IU
storage temp.   2-8°C
Gene Information   cow ... TSHB(281552)
human ... TSHR(7253)

Description

Biochem/physiol Actions

Thyrotropic hormone or Thyroid stimulating hormone (TSH) belongs to glycoprotein hormone family. The product can enhance vascular endothelial growth factor (VEGF) secretion and angiogenesis in thyroid cancer cell lines.

Two-chain glycoprotein hormone. The α-chain is not active, biological specificity attributed rather to the β-chain. Activates adenylate cyclase in the thyroid gland, stimulating iodine uptake, thyroxine synthesis and release. Goitrogenic.

Packaging

1 vial in serum bottle

10 vials in serum bottle

Quality

Contains phosphate buffer salts

Application

Thyrotropic hormone from bovine pituitary can be used for TSH stimulation test for assessing the thyroid gland function after NTI induction. The product was injected in 4-week-old male C57BL/6J and CBA/N mice for studying the thyrotropin involvement in photoperiodic signal transduction.

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Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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