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T8949 Sigma

Telmisartan

≥98% (HPLC), solid

Synonym: 4′[(1,4′-Dimethyl-2′-propyl[2,6′-bi-1H-benzimidazol]-1′-yl)methyl][1,1′-biphenyl]-2-carboxylic acid, BIBR 277

  • CAS Number 144701-48-4

  • Empirical Formula (Hill Notation) C33H30N4O2

  • Molecular Weight 514.62

  •  MDL number MFCD00918125

Description

Biochem/physiol Actions

Telmisartan is a non-peptide AT1 angiotensin receptor antagonist.

Preparation Note

Telmisartan is soluble in DMSO at a concentration that is greater than 5 mg/ml. It is insoluble in water.

Application

Telmisartan has been used as an AT1 receptor antagonist to study its effects on mouse models of myocardial infarction. This study reported that telmisartan inhibited the CCN1 upregulation and reduced CCN2 levels atrial cardiomyocytes1. Telmisartan has also been used to evaluate its effect on the expression of CCN1 in kidney cortex of mice subjected to myocardial infarction2. Furthermore, telmisartan has been used to test its efficacy against tumor growth in mouse models of colorectal cancer3.

Features and Benefits

This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Price and Availability

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Telmisartan
Y0000648Telmisartan

European Pharmacopoeia (EP) Reference Standard

Telmisartan for peak identification

European Pharmacopoeia (EP) Reference Standard

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