|Related Categories||Antagonists, Bioactive Small Molecules, Biochemicals and Reagents, Calcium Channel Modulators, Cell Biology,|
|solubility||H2O: soluble250 mg plus 5 ml of solvent, clear, colorless to faintly yellow|
|diethyl ether: insoluble|
|Gene Information||human ... DRD2(1813)|
250 mg of thioridazine hydrochloride is soluble in 5 ml of water and yields a clear, colorless to faint yellow solution. Thioridazine hydrochloride is also soluble in methanol, ethanol, and chloroform, but it is insoluble in ether.
Thioridazine hydrochloride has been used as an intercalating agent for analyzing the integrity of double-stranded DNA (dsDNA) using square-wave voltammetry (SWV) techniques1. Thioridazine hydrochloride has also been used as a positive control for the inhibition of hepatic enzyme cytochrome P4502D6 (CYP2D6) in human liver microsomes2.
D2 dopamine receptor antagonist; phenothazine antipsychotic with reduced extrapyramidal side effects; Ca2+ channel blocker.
Certificate of Analysis
Certificate of Origin
|Precautionary statements||P261-P273-P305 + P351 + P338-P501|
|Personal Protective Equipment||dust mask type N95 (US), Eyeshields, Gloves|
|Hazard Codes (Europe)||Xn,N|
|Risk Statements (Europe)||22-36/37/38-50/53|
|Safety Statements (Europe)||26-36-60-61|
|RIDADR||UN 3077 9 / PGIII|
1. Evaluation of damage to DNA induced by UV-C radiation and chemical agents using electrochemical biosensor based on low molecular weight DNA and screen-printed carbon electrode. Hlavata, L., et al. Electrochim. Acta 71, 134-139, (2012)
2. The effect of selective serotonin re-uptake inhibitors on cytochrome P4502D6 (CYP2D6) activity in human liver microsomes. Crewe HK, Lennard MS, Tucker GT, et al. Br. J. Clin. Pharmacol. 34(3), 262-5, (1992)
Effects of Ca(2+)-ionophore A23187 and calmodulin antagonists on regulatory mechanisms of glycolysis and cell viability of NIH-3T3 fibroblasts. Ashkenazy-Shahar, et al. Mol. Genet. Metab. 67, 334-342, (1999)
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