|Related Categories||Antibodies, Antibody Purification and Characterization, Carrier Proteins, Supplementary Products|
|mol wt||mol wt ~670 kDa|
|Gene Information||cow ... TG(280706)|
Often used as a carrier protein for the production of antibodies. Its advantage is the large number of tyrosine residues that can be used for conjugation using the diazo reaction.
Thyroglobulin is used for antibody purification and characterization. Thyroglobulin has been used in studies assessing the monitoring of differentiated thyroid cancer as well as to develop an accurate diagnostic tool for patients with autoimmune thyroid diseases.
Iodine-containing protein that is stored in the thyroid gland. Converted into circulating thyroxines when the thyroid is stimulated by thyroid-stimulating hormone (TSH) from the pituitary. Because its expression is unique to the thyroid, it is a sensitive indicator of recurrence or metastasis of thyroid cancer that has been treated by thyroid ablation.1
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Keywords: Buffers, Cell biology, Epigenetics, Immunohistochemistry, Immunoprecipitation, Molecular biology, Neuroscience, Western blot
Postoperative-stimulated serum thyroglobulin measured at the time of 131I ablation is useful for the prediction of disease status in patients with differentiated thyroid carcinoma. Lee JI, Chung YJ, Cho BY, et al. Surgery 153(6), 828-35, (2013)
A clinically euthyroid child with a large goiter due to a thyroglobulin gene defect: clinical features and genetic studies. Hermanns P, Refetoff S, Sriphrapradang C, et al. J. Pediatr. Endocrinol. Metab. 26(1-2), 119-23, (2013)
Thyroglobulin in smoking mothers and their newborns at delivery suggests autoregulation of placental iodide transport overcoming thiocyanate inhibition. Andersen SL, Nøhr SB, Wu CS, et al. Eur. J. Endocrinol. 168(5), 723-31, (2013)
The value of serum thyreoglobulin levels and whole body (I-131) scintigraphy in the follow-up of the thyroid cancer patients after thyroidectomy. Kucukalić-Selimović E, Alagić J, Valjevac A, et al. Coll. Antropol. 36 Suppl 2, 67-71, (2012)
Importance of measurement of thyroglobulin and anti-thyroglobulin antibodies in differentiated thyroid cancer. Alagić-Smailbegović J, Kucukalić-Selimović E, Setić I, et al. Coll. Antropol. 36 Suppl 2, 33-8, (2012)
Measurement of thyroglobulin by liquid chromatography-tandem mass spectrometry in serum and plasma in the presence of antithyroglobulin autoantibodies. Kushnir MM, Rockwood AL, Roberts WL, et al. Clin. Chem. 59(6), 982-90, (2013)
Thyroglobulin in washout fluid from lymph node fine-needle aspiration biopsy in papillary thyroid cancer: large-scale validation of the cutoff value to determine malignancy and evaluation of discrepant results. Moon JH, Kim YI, Lim JA, et al. J. Clin. Endocrinol. Metab. 98(3), 1061-8, (2013)
Prognostic significance of FDG PET/CT on the follow-up of patients of differentiated thyroid carcinoma with negative I131 whole-body scan and elevated thyroglobulin levels. Caobelli F, Pizzocaro C, and Guerra UP Clin. Nucl. Med. 38(3), 196, (2013)
Prognostic significance of FDG PET/CT on the follow-up of patients of differentiated thyroid carcinoma with negative I131 whole- body scan and elevated thyroglobulin levels. Marcus CS Clin. Nucl. Med. 38(3), 195, (2013)
Efficacy analysis of (131)I therapy and predictive value of preablation stimulated thyroglobulin for lung metastases from differentiated thyroid cancer. Wu S and Wang H Ann. Endocrinol. (Paris.) 74(1), 40-4, (2013)
Development, characterization and clinical validation of new sensitive immunofluorometric assay for the measurement of serum thyroglobulin. Nakabashi CC, Biscolla RP, Kasamatsu TS, et al. Arq. Bras. Endocrinol. Metabol. 56(9), 658-65, (2012)
Maternal and umbilical cord levels of T4, FT4, TSH, TPOAb, and TgAb in term infants and neurodevelopmental outcome at 5.5 years. Williams FL, Watson J, Ogston SA, et al. J. Clin. Endocrinol. Metab. 98(2), 829-38, (2013)
Humanized medium (h7H) allows long-term primary follicular thyroid cultures from human normal thyroid, benign neoplasm, and cancer. Bravo SB, Garcia-Rendueles ME, Garcia-Rendueles AR, et al. J. Clin. Endocrinol. Metab. 98(6), 2431-41, (2013)
Thyroglobulin is a sensitive measure of both deficient and excess iodine intakes in children and indicates no adverse effects on thyroid function in the UIC range of 100-299 μg/L: a UNICEF/ICCIDD study group report. Zimmermann MB, Aeberli I, Andersson M, et al. J. Clin. Endocrinol. Metab. 98(3), 1271-80, (2013)
Relationship between urinary triclosan and paraben concentrations and serum thyroid measures in NHANES 2007-2008. Koeppe ES, Ferguson KK, Colacino JA, et al. Sci. Total Environ. 445-446, 299-305, (2013)
[Assessment of recombinant human thyrotropin application in following-up patients with well-differentiated thyroid carcinoma]. Rajkovaca Z, Kovacević P, Stanetić M, et al. Vojnosanit. Pregl. 69(11), 941-6, (2012)
Hashimoto's thyroiditis: similar and dissimilar characteristics in neighboring areas. Possible implications for the epidemiology of thyroid cancer. Latina A, Gullo D, Trimarchi F, et al. PLoS ONE 8(3), e55450, (2013)
Correlation of 18F-FDG PET/CT findings with histopathological results in differentiated thyroid cancer patients who have increased thyroglobulin or antithyroglobulin antibody levels and negative 131I whole-body scan results. Ozkan E, Aras G, and Kucuk NO Clin. Nucl. Med. 38(5), 326-31, (2013)
Papillary thyroid microcarcinoma presenting as lymph node metastasis--a diagnostic challenge: case report and systematic review of literature. Anastasilakis AD, Polyzos SA, Makras P, et al. Hormones (Athens.) 11(4), 419-27, (2012)
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