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T9197 Sigma

Tissue Inhibitor of Metalloproteinase-3 human

>95% (SDS-PAGE), recombinant, expressed in BHK cells, buffered aqueous solution

Synonym: TIMP-3

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Properties

recombinant   expressed in BHK cells
assay   >95% (SDS-PAGE)
form   buffered aqueous solution
mol wt   glycosylated form mol wt ~30 kDa
  mol wt ~23 kDa (unglycosylated form)
shipped in   wet ice
storage temp.   −20°C
Gene Information   human ... TIMP3(7078)

Description

Biochem/physiol Actions

The TIMPs are endogenous inhibitors of the matrix metalloproteinases (MMPs). TIMP-3 inhibits ADAM-17 (TACE) at nanomolar concentrations and also inhibits other metalloproteinases (sheddases) that mediate the shedding of soluble receptors and other proteins from the surface of cells.

Physical form

Supplied in acitve form, in 10 mM MES, pH 5.0, 100 mM sodium chloride, 0.02% Brij-35 and 50% glycerol.

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Safety & Documentation

Safety Information

WGK Germany 
1

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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T1327 Tissue Inhibitor of Metalloproteinase-3 human, recombinant, expressed in NSO cells, >95% (SDS-PAGE)

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