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T9265 Sigma

Thyrotropic hormone from human pituitary

lyophilized powder, ~7 IU/mg (RIA)

Synonym: TSH, Thyroid stimulating hormone

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, Pituitary Hormones,
form   lyophilized powder
storage temp.   −20°C
Gene Information   human ... TSHB(7252), TSHR(7253)

Description

Biochem/physiol Actions

Two-chain glycoprotein hormone. The α-chain is not active, biological specificity attributed rather to the β-chain. Activates adenylate cyclase in the thyroid gland, stimulating iodine uptake, thyroxine synthesis and release. Goitrogenic.

Thyrotropic hormone or Thyroid stimulating hormone (TSH) belongs to glycoprotein hormone family. The product can enhance vascular endothelial growth factor (VEGF) secretion and angiogenesis in thyroid cancer cell lines.

Packaging

Package size based on hormone

Physical form

Contains hormone and salts from approx. 0.1 mL of 0.05 M phosphate buffer, pH 7.4.

Application

Thyrotropic hormone from human pituitary also referred to as TSH can be used as a medium supplement for primary cell culture, and is used further to study the molecular mechanisms of estrogen-mediated growth stimulation of human thyroid tumor cells.

Price and Availability


All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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Product #

Description

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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