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T9444 Sigma

TECK from mouse

>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

Synonym: Thymus-expressed chemokine

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Chemokines, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones,
recombinant   expressed in E. coli
assay   >97% (SDS-PAGE)
form   lyophilized powder
mol wt   mol wt 16-17 kDa by SDS-PAGE (doublet)
  predicted mol wt ~14 kDa
impurities   endotoxin, tested
storage temp.   −20°C
Gene Information   mouse ... Ccl25(20300)

Description

Analysis Note

The biological activity is measured by its ability to chemoattract hCCR9 transfected BaF/3 cells.

Biochem/physiol Actions

TECK, a CC chemokine, is chemotactic for activated macrophages, dendritic cells, and thymocytes.

Thymus-expressed chemokine (TECK) belongs to CC chemokine and is expressed mainly in thymus and small intestine. It can facilitate chemotaxis of human G protein-coupled receptor GPR-9-6/L1.2 transfectants. Further, TECK potentially assists in T Cell Development.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing at least 50 μg bovine serum albumin per 1 μg of cytokine.

Application

The interaction of TECK and its receptor CCR9 plays a pivotal role in recruiting the developing thymocytes to their distinct compartment of the thymus.

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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