|Related Categories||Alphabetical Index, Antibodies, Antibodies for Alzheimer′s Disease, Antibodies for Cell Biology, Antibodies for Neural Stem Cells,|
|species reactivity||mouse, human, rat, bovine|
|indirect ELISA: suitable|
|western blot: 0.5-1 μg/mL using mouse brain extract|
|antibody form||purified immunoglobulin|
|form||buffered aqueous solution|
|shipped in||dry ice|
human ... MAPT(4137)|
mouse ... Mapt(17762)
rat ... Mapt(29477)
Tau is a family of microtubule-associated proteins thought to regulate the stability and organization of microtubules in neuronal cells. The tau protein family is derived from alternative mRNA splice variants that originate from a single gene, and result in mature proteins that vary in size from 352 to 441 amino acids (45 to 60 kDa). Tau loses microtubule-binding activity and aggregates into paired helical filaments (PHFs) in neurodegenerative disorders. PHFs are the basic structural components of neurofibrillary tangles (NFTs). NFT accumulation correlates with the clinical progression of Alzheimer′s disease. Phosphorylation can affect the functional properties of tau and hyperphosphorylation of tau may result in the loss of tau’s microtubule binding activity and the formation of the insoluble aggregates. Hyperphosphorylation and nonenzymatic glycosylation are posttranslational modifications detected in PHF-tau, and numerous sites of hyperphosphorylation of both normal and PHF-tau have been identified.
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Mouse monoclonal clone Tau46 anti-Tau antibody recognizes bovine, rat, human, and mouse Tau (approx. 45 to 60 kDa). The antibody recognizes a phosphorylation-independe
Mouse monoclonal clone Tau46 anti-Tau antibody is useful in ELISA, immunoblotting, immunogold labeling, immunopreciptation as well as immunohistochemistry. It is used as a probe to determine the presence and roles of Tau protein in the regulation of the stability and organization of microtubules in neuronal cells.
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~1 mg/mL, affinity isolated antibody, buffered aqueous solution
clone TAU-2, ascites fluid
recombinant, expressed in E. coli, ≥90% (SDS-PAGE), lyophilized powder
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Keywords: Buffers, Cell biology, Epigenetics, Immunohistochemistry, Immunoprecipitation, Molecular biology, Neuroscience, Western blot
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