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T9694 Sigma

TARC from mouse

>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder

Synonym: Thymus and activation-regulated chemokine

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Chemokines, Cytokines and Growth Factors, Cytokines, Growth Factors and Hormones,
recombinant   expressed in E. coli
assay   >97% (SDS-PAGE)
form   lyophilized powder
mol wt   predicted mol wt ~7.9 kDa
impurities   endotoxin, tested
storage temp.   −20°C
Gene Information   mouse ... Ccl17(20295)

Description

Analysis Note

The biological activity is measured by its ability to induce chemotaxis of human CEM NKR cells.

Physical form

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% TFA containing 1.25 mg bovine serum albumin.

Application

Mouse TARC (thymus and activation regulated chemokine) is a ligand for CC chemokine receptor 4 and is a potent and selective chemoattractant to helper T cells leading to their migration through the early phase of the immune response.

Biochem/physiol Actions

TARC is a CC chemokine that mediates the hippocampal-neuron survival in the CNS. It also enhances the CTACK-inducing effect of TNF-α in keratinocytes. Additionally, chemokines can modify trafficking (chemotaxis) of leukocytes, especially systemic T cells.

TARC, a CC chemokine and the ligand for CCR-4, is a receptor that is selectively expressed on T cells and chemotactic for T cell lines.

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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