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T9827 Sigma

TYRO3 (455-end), active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym: BYK, Brt, Dtk, RSE, Sky, Tif

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Properties

Related Categories Active Kinases, Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes,
recombinant   expressed in baculovirus infected Sf9 cells
grade   PRECISIO® Kinase
assay   ≥70% (SDS-PAGE)
form   buffered aqueous glycerol solution
activity   131-178 nmol/min·mg
mol wt   mol wt ~77 kDa
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... TYRO3(7301)

Description

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Application

TYRO3 (455-end), active, GST tagged human is a member of Tyrosine protein kinase family and plays a pivotal role in many physiological processes like- spermatogenesis, immunoregulation, and phagocytosis. TYRO3 interacts with murine Gas6 and plays an essential role in arterial thrombus formation.

Biochem/physiol Actions

TYRO3 receptor protein tyrosine kinase together with AXL and MER form the AXL/TYRO3 family of receptor tyrosine kinases. Members of this family play an essential role in spermatogenesis, immunoregulation, and phagocytosis. In addition to signal transduction, members of this family of receptor tryrosine kinases participate in cell adhesion. Gas6, a product of growth arrest-specific gene, activates the kinase activity of all three receptors. TYRO3 is expressed in the brain (where it is involved in the protection of neurons from apoptosis), expressed in lymphoid, vascular and reproductive tissue and in primary and tumor cell lines. Members of the Tyro3 receptor tyrosine kinase family like-dtk facilitate the cell entry of Ebola and Marburg Viruses.

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