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T9952 Sigma

TXK (239-end), active, GST tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym: BTKL, MGC22473, PSCTK5, PTK4, RLK, TKL

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Properties

Related Categories Active Kinases, Application Index, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes,
recombinant   expressed in baculovirus infected Sf9 cells
grade   PRECISIO® Kinase
assay   ≥70% (SDS-PAGE)
form   buffered aqueous glycerol solution
activity   15-21 nmol/min·mg
mol wt   mol wt ~53 kDa
shipped in   dry ice
storage temp.   −70°C
Gene Information   human ... TXK(7294)

Description

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Application

Txk can lead to increased Th1 cell function, which is seen in patients with Behcet′s disease. Hence, it can be used in the pathogenesis of Behcet′s disease.

Biochem/physiol Actions

TXK also known as RLK or PTK4 belongs to nonreceptor tyrosine kinase of the Tec family which helps in regulating the PI 3-kinase binding to T-cell antigen, CTLA-4 by phosphorylating the YVKM motif. Additionally, TXK along with EF-1α and PARP1 forms a complex, which binds to the IFN-γ gene promoter and regulates the interferon-γ gene transcription in Th1 cells.

Legal Information

PRECISIO is a registered trademark of Sigma-Aldrich Co. LLC

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