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U1008 Sigma

Urocortin III human

≥97% (HPLC)

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Properties

Related Categories CRF, Cell Biology, Cell Signaling and Neuroscience, Neuropeptides, Peptides and Proteins,
assay   ≥97% (HPLC)
form   solid
storage temp.   −20°C
Gene Information   human ... UCN3(114131)

Description

Amino Acid Sequence

Phe-Thr-Leu-Ser-Leu-Asp-Val-Pro-Thr-Asn-Ile-Met-Asn-Leu-Leu-Phe-Asn-Ile-Ala-Lys-Ala-Lys-Asn-Leu-Arg-Ala-Gln-Ala-Ala-Ala-Asn-Ala-His-Leu-Met-Ala-Gln-Ile-NH2

Biochem/physiol Actions

Selective ligand with high affinity for CRF2 Receptors

Urocortin III belongs to corticotropin-releasing hormone family with high affinity for the type 2 corticotropin-releasing factor (CRFR2) receptor. It stimulates insulin and glucagon secretion.Urocortin III also possesses cardioprotective property and has minimal impact on the hypothalamic stress axis. It is, therefore, utilized for treating ischemic heart disease.

Other Notes

Lyophilized from 0.1% TFA in H2O

Application

Urocortin III human can be used as a test compound for studying the impacts of melanocortin agonist on in vitro α-subunit secretion.

Price and Availability


Amplified Detection

Amicon Ultra Centrifugal Filters
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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