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U103 Sigma

U-69593

solid

Synonym: (+)-(5α,7α,8β)-N-Methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4.5]dec-8-yl]-benzeneacetamide, U69593

  • CAS Number 96744-75-1

  • Empirical Formula (Hill Notation) C22H32N2O2

  • Molecular Weight 356.50

  •  MDL number MFCD05664586

  •  PubChem Substance ID 24278769

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   PGZRDDYTKFZSFR-ONTIZHBOSA-N
form   solid
optical activity   [α]/D +7.8°, c = 0.825 in methanol(lit.)
color   white
solubility   45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 10 mg/mL
  0.1 M HCl: >40 mg/mL
  ethanol: >40 mg/mL
  0.1 M NaOH: insoluble
  H2O: insoluble
storage temp.   2-8°C
Gene Information   human ... OPRD1(4985), OPRK1(4986), OPRM1(4988)
mouse ... Oprk1(18387)
rat ... Oprd1(24613), Oprk1(29335), Oprm1(25601)

Description

Packaging

25 mg in poly bottle

5 mg in glass bottle

Preparation Note

U-69593 is soluble in 45% (w/v) aq 2-hydroxypropyl-β-cyclode

Biochem/physiol Actions

U-69593 is a selective κ opioid receptor agonist. U-69593 is known to inhibit cocaine sensitization in meso-limbic dopamine neurons by normalizing basal overflow of dopamine.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

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Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
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Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
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References

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