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U104 Sigma

UK 14,304

Synonym: 5-Bromo-N-(2-imidazolin-2-yl)-6-quinoxalinamine, 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine, Brimonidine

  • CAS Number 59803-98-4

  • Empirical Formula (Hill Notation) C11H10BrN5

  • Molecular Weight 292.13

  •  MDL number MFCD00153878

  •  PubChem Substance ID 24277812

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Properties

Related Categories Adrenergics, Adrenergics - Agonists, Agonists, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules,
InChI Key   XYLJNLCSTIOKRM-UHFFFAOYSA-N
solubility   45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: <0.8 mg/mL
  DMSO: >6.5 mg/mL
  ethanol: <8 mg/mL (warm)
  H2O: insoluble
Gene Information   human ... ADRA1A(148), ADRA2A(150), ADRA2B(151), ADRA2C(152)

Description

Biochem/physiol Actions

UK 14,304 is an α2-adrenoceptor agonist.

Packaging

5, 25, 100 mg in glass bottle

Preparation Note

UK 14,304 is soluble in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (<0.8 mg/mL), DMSO (>6.5 mg/ml) and ethanol (<8 mg/mL). However, it is insoluble in water.

Application

UK 14,304 has been used in myenteric neurons to study the inhibition of R-type calcium currents. UK 14,304 has also been used for immunofluorescence microscopy assays.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

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Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
1

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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