Antibodies against Adhesion, Attachment, and Matrix Factors,
Antibodies against Proteins/Bioactives/Marke|
|species reactivity||human, bovine, canine, mouse|
|application(s)||immunohistochemistry (frozen sections): suitable|
|indirect immunofluorescence: 1:1,600 using cultured MDCK cells|
|western blot: suitable|
|antibody form||ascites fluid|
|form||buffered aqueous solution|
|contains||15 mM sodium azide|
|shipped in||dry ice|
human ... CDH1(999)|
mouse ... Cdh1(12550)
mouse embryonal carcinoma cell line PCC4 Aza R1.
Cell-cell interactions during embryonic development and in tissue organization involve specific cell-adhesion molecules (CAMs) that are functionally defined by antibodies that interfere with cell-cell adhesion. CAMs are expressed on early embryonic cells and persist in derivatives of all three germ layers. The best characterized CAMs are N-CAM (neural CAM) and L-CAM (liver CAM). The protein uvomorulin, initially identified in embryonal carcinoma, is identical to E-Cadherin, L-CAM, Cell CAM 80/120, and ARC-1, each of which have been characterized in different systems. Uvomorulin/E-Cadherin has been characterized as a 120 kDa cell surface glycoprotein from which an 84 kDa fragment can be released by trypsin digestion in the presence of Ca2+.
The antibody localizes the cell surface glycoprotein uvomorulin/E-cadherin that has been found to be identical to L-CAM, Cell CAM 80/120, and ARC-1. The antibody may be used for studies of embryonal development, cell-cell interactions of cultured cells, and localization of uvomorulin/E-cadherin in immunoblotting or immunohistochemical assays.
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Keywords: Buffers, Cell biology, Epigenetics, Immunohistochemistry, Immunoprecipitation, Molecular biology, Neuroscience, Western blot
Nuclear localization of the p120(ctn) Armadillo-like catenin is counteracted by a nuclear export signal and by E-cadherin expression. Hengel, J.V., et al. Proc. Natl. Acad. Sci. U. S. A. 96, 7980, (1999)
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