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U4127 Sigma

Urocortin human

≥85% (HPLC), powder

  • CAS Number 176591-49-4

  • Empirical Formula (Hill Notation) C204H337N63O64

  • Molecular Weight 4696.24

  •  MDL number MFCD00802621

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Properties

Related Categories CRF, Cell Biology, Cell Signaling and Neuroscience, Neuropeptides, Peptides and Proteins,
assay   ≥85% (HPLC)
form   powder
storage temp.   −20°C
Gene Information   human ... UCN(7349)

Description

Amino Acid Sequence

Asp-Asn-Pro-Ser-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2

Packaging

250 μg in glass bottle

Application

Urocortin human can be used as a test compound for studying the impact of corticotropin-releasing factor (CRF) receptor agonist and antagonist on sleep-wake patterns in conscious rats by using radiotelemetry system.

Biochem/physiol Actions

Binds to CRF receptor types 1, 2α, and 2β; stimulates cAMP accumulation from cells transfected with these receptors. Acts in vitro to release ACTH from rat anterior pituitary cells.

Urocortin is a CRF-related neuropeptide having high affinity for CRF2 receptor possess appetite-suppressing effect. Urocortin along with corticotropin-releasing factor (CRF) binding protein (CRF-BP) enhances the free CRF levels in human brain by displacing hCRF from the binding protein.

Price and Availability


Detect Your Unseen Protein

All labs need water

Amicon Ultra Centrifugal Filters
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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