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U4127 Sigma

Urocortin human

≥85% (HPLC), powder

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  • CAS Number 176591-49-4

  • Empirical Formula (Hill Notation) C204H337N63O64

  • Molecular Weight 4696.24

  •  MDL number MFCD00802621

Properties

Related Categories CRF, Cell Biology, Cell Signaling and Neuroscience, Neuropeptides, Peptides and Proteins,
assay   ≥85% (HPLC)
form   powder
storage temp.   −20°C
Gene Information   human ... UCN(7349)

Description

Amino Acid Sequence

Asp-Asn-Pro-Ser-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2

Biochem/physiol Actions

Binds to CRF receptor types 1, 2α, and 2β; stimulates cAMP accumulation from cells transfected with these receptors. Acts in vitro to release ACTH from rat anterior pituitary cells.

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