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U5754 Sigma

Urodilatin human

≥97% (HPLC)

Synonym: Thr-Ala-Pro-Arg-Atrial Natriuretic Peptide

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Natriuretic Peptides, Neuropeptides, Peptides and Proteins,
InChI Key   IUCCYQIEZNQWRS-DWWHXVEHSA-N
assay   ≥97% (HPLC)
composition   Peptide content, ~70%
storage temp.   −20°C
Gene Information   human ... NPPA(4878)

Description

Amino Acid Sequence

Thr-Ala-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr [Disulfide Bridge: 11-27]

Application

Human Urodilatin can be used as a test compound for examining the activity and mechanisms of action of urodilatin in bovine bronchi. It used to investigate the effect on bronchodilatation and protect against subsequent challenge with alpha-human atrial natriuretic peptide (ANP).

Biochem/physiol Actions

Urodilatin is a natriuretic factor belongs to atrial natriuretic peptide family which along with four cardiac hormones decreases human renal carcinoma cell numbers. Urodilatin induces cGMP synthesis as well as stimulates cGMP accumulation by threefold in inner medullary collecting ducts (IMCD).

Urodilatin is a natriuretic factor that is produced in the kidney and secreted into the urine. It regulates water and sodium reabsorption in the collecting duct.

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