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U6508 Sigma

UCN-01

≥97% (HPLC), powder

Synonym: KW-2401

  • CAS Number 112953-11-4

  • Empirical Formula (Hill Notation) C28H26N4O4

  • Molecular Weight 482.53

  •  PubChem Substance ID 24724639

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology,
InChI Key   PBCZSGKMGDDXIJ-KRUBCLEUSA-N
assay   ≥97% (HPLC)
form   powder
storage condition   protect from light
color   light yellow
solubility   DMSO: >5 mg/mL
  H2O: insoluble
storage temp.   2-8°C

Description

Biochem/physiol Actions

UCN-01 is a selective inhibitor for conventional PKC isotypes over novel PKC isotypes.

Preparation Note

UCN-01 is soluble in DMSO at a concentration that is greater than 5 mg/ml. However, it is insoluble in water.

Application

UCN-01 has been used to study checkpoint kinase-1 (CHK1) protein function in trophoblast stem (TS) cells. It has also been used to study UV-induced CHK1 phosphorylation in IB10 cells.

Features and Benefits

This compound is featured on the PKB/Akt and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Price and Availability

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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