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U6631 Sigma

Urocortin rat

≥97% (HPLC), powder

  • CAS Number 171543-83-2

  • Empirical Formula (Hill Notation) C206H338N62O64

  • Molecular Weight 4707.26

  •  MDL number MFCD00678232

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Properties

Related Categories CRF, Cell Biology, Cell Signaling and Neuroscience, Neuropeptides, Peptides and Proteins,
assay   ≥97% (HPLC)
form   powder
solubility   1% acetic acid: >1 mg/mL, clear, colorless
storage temp.   −20°C
Gene Information   rat ... Ucn(29151)

Description

Amino Acid Sequence

Asp-Asp-Pro-Pro-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2

Other Notes

Lyophilized from 0.1% TFA in H2O

Preparation Note

Urocortin rat dissolves in 1% acetic acid at 1 mg/ml to yield a clear, colorless solution.

Application

Urocortin rat can be used for western blotting. The product can also be used for studying that whether CRF receptor type 2 (CRF2) and its high-affinity ligand, urocortin 1 (Ucn1) can mediate sex-specific cellular stress responses by using corticotropin-releasing factor receptor 2-deficient (Crhr2-/- ) and wild-type (WT) mice.

Biochem/physiol Actions

Binds to CRF receptor types 1, 2α, and 2β; stimulates cAMP accumulation from cells transfected with these receptors. Acts in vitro to release ACTH from rat anterior pituitary cells.

Urocortin is a CRF-related neuropeptide that binds to CRF receptor types 1α, 2α and 2β. It possesses appetite-suppressing effect. Urocortin along with corticotropin-releasing factor (CRF) binding protein (CRF-BP) enhances the free CRF levels in human brain by displacing hCRF from the binding protein.

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Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
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