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U6756 Sigma

U-73122 hydrate

powder

Synonym: 1-[6-[((17β)-3-Methoxyestra-1,3,5[10]-trien-17-yl)amino]hexyl]-1H-pyrrole-2,5-dione

Properties

Related Categories Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors,
form   powder
color   off-white
solubility   ethanol: ~.7 mg/mL
  DMSO: ~.9 mg/mL
  chloroform: ~10 mg/mL
  DMSO: ≤2.6 mg/mL (Achieved with heating.)
  ethanol: ≤5 mg/mL (Achieved with heating.)
  H2O: insoluble
storage temp.   room temp

Description

Biochem/physiol Actions

Inhibits the hydrolysis of PPI to IP3, which leads to a decrease in cytosolic free calcium. Inhibits the coupling of G protein-phospholipase C activation, while remaining unaffected by production of cAMP.

Preparation Note

U-73122 hydrate is soluble in ethanol (approx. 0.7 mg/ml or ≤ 5 mg/ml with heating), chloroform (approx. 10 mg/ml) and DMSO (approx. 0.9 mg/ml or ≤ 2.6 mg/ml with heating). U-73122 hydrate is insoluble in water.

Application

U-73122 hydrate has been used for studying the role of phospholipase C (PLC) signaling in modulating epithelial Na+ channel (ENaC) function in gerbil Reissner′s membranes (RMs)1. U-73122 has also been used to study local calcium responses in human umbilical vein endothelial cells (HUVECs)2.

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