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U7257 Sigma

Urotensin II human

≥97% (HPLC), synthetic

  • Empirical Formula (Hill Notation) C64H85N13O18S2

  • Molecular Weight 1388.57

  •  MDL number MFCD04115626

  •  PubChem Substance ID 329827647

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Properties

Related Categories CRF, Cell Biology, Cell Signaling and Neuroscience, Neuropeptides, Peptides and Proteins,
biological source   synthetic
InChI Key   HFNHAPQMXICKCF-USJMABIRSA-N
assay   ≥97% (HPLC)
storage temp.   −20°C
Gene Information   human ... UTS2(10911)

Description

Amino Acid Sequence

Glu-Thr-Pro-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val [Disulfide Bridge: 5-10]

Other Notes

Lyophilized from 0.1% TFA in H2O

Packaging

0.5, 1 mg in poly bottle

Application

Urotensin II human was used in agonist and antagonist preparation for calcium mobilization assay. The product can also be used as a test compound for studying the impact of dihydropyridine calcium antagonist amlodipine in human internal mammary artery and clinical implications.

Biochem/physiol Actions

A neuroendocrine peptide of the CRF family that was originally isolated from fish brain but is also found in mammalian brain and spinal motor neurons. It is a potent vasoconstrictor. It may be a mediator of stress-induced anorexia.

Human urotensin II is a vasoactive neuropeptide that belongs to CRF family and stimulates arterial smooth muscle contraction, actin stress fiber formation and proliferation via small GTPase RhoA and there downstream effector Rho-kinase activation.The product is also a selective and potent vasoconstrictor agent as well as an agonist for the orphan receptor GPR14.

Price and Availability


Amplified Detection

Making Headway

All labs need water
Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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