UC167 Sigma

Oxidized Nifedipine

powder, ~95% (HPLC)

Synonym: 2,6-Dimethyl-4-(2´-nitrophenyl)-3,5-pyridinecarboxylic acid dimethyl ester

  • CAS Number 67035-22-7

  • Empirical Formula (Hill Notation) C17H16N2O6

  • Molecular Weight 344.32

  •  MDL number MFCD00153847



Biochem/physiol Actions

CYP3A4 nifedipine metabolite. Nifedipine (parent compound) is an antianginal and antihypertensive agent.


Bottomless glass bottle. Contents are inside inserted fused cone.


Oxidized nifedipine has been used for apoptotic signaling studies in dopaminergic neurons1.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. UC167.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit

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Safety & Documentation

Safety Information

GHS05  GHS05
Signal word 
Hazard statements 
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Protocols & Articles
Peer-Reviewed Papers


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1. Nuclear translocation of nuclear transcription factor-kappa B by alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors leads to transcription of p53 and cell death in dopaminergic neurons. de Erausquin GA, Hyrc K, Dorsey DA, et al. Mol. Pharmacol. 63(4), 784-90, (2003)


Cooke, A.H., et al. J. Chem. Soc., 413, (1943)

Enhancement of CYP3A4 activity in Hep G2 cells by lentiviral transfection of hepatocyte nuclear factor-1 alpha. Chiang TS, Yang KC, Chiou LL, et al. PLoS ONE 9(4), e94885, (2014)


Interactions of endosulfan and methoxychlor involving CYP3A4 and CYP2B6 in human HepaRG cells. Savary CC, Jossé R, Bruyère A, et al. Drug Metab. Dispos. 42(8), 1235-40, (2014)


Delamanid does not inhibit or induce cytochrome p450 enzymes in vitro. Shimokawa Y, Sasahara K, Yoda N, et al. Biol. Pharm. Bull. 37(11), 1727-35, (2014)


Structure-function analysis of porcine cytochrome P450 3A29 in the hydroxylation of T-2 toxin as revealed by docking and mutagenesis studies. Cheng G, Liu C, Wang X, et al. PLoS ONE 9(9), e106769, (2014)


Da-Chaihu-Tang alters the pharmacokinetics of nifedipine in rats and a treatment regimen to avoid this. He JX, Ohno K, Tang J, et al. J. Pharm. Pharmacol. 66(11), 1623-30, (2014)


Species differences and substrate specificity of CYP3A heteroactivation by efavirenz. Kosugi Y, Takahashi J, et al. Xenobiotica 45(4), 345-52, (2015)


Occurrence and measurement of nifedipine and its nitropyridine derivatives in human blood plasma. Dokladalova J, Tykal JA, Coco SJ, et al. J. Chromatogr. A. 231(2), 451-8, (1982)


The first pass metabolism of nifedipine in man. Waller DG, Renwick AG, Gruchy BS, et al. Br. J. Clin. Pharmacol. 18(6), 951-4, (1984)


Isotopic sensitivity in the microsomal oxidation of the dihydropyridine calcium entry blocker nifedipine. Born JL and Hadley WM Chem. Res. Toxicol. 2(1), 57-9, (1989)


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